And you have not changed your account name (= user profile)?
Since v10.20 the UltraEdit configuration files are in the user specific and by Windows default hidden application data directory if there is no uedit32.ini from a previous installation anywhere else - see UltraEdit INI file location
. Also if you save/load the settings to/from registry they are stored at HKEY_CURRENT_USER and so are user profile specific.
Check again if you do not use the /I command line parameter, the UEINIDIR environment variable or you have an uedit32.ini in the UE program or Windows directory. You also have hopefully not changed the program file name of Uedit32.exe because the default INI name is in real "program file name.ini".
But maybe simply the INI file was corrupt or deleted by you or an other application by mistake and so UltraEdit created a new one with the default settings.
Scanning the hard disk for errors with Windows ScanDisk periodically (once per month), using S.M.A.R.T. and a drive image program is always a good idea to detect the start of the death of an hard disk before data losses occur. The system hard disk at home died for 2 years. I could save all files which were newer as the last drive image backup before it was too late. After 30 minutes of mounting the new hard disk, restore the drive image from the backup hard disk and copying the extra saved files back, my computer worked again with the new hard disk without any data loss. I spent too much time into the setup of my computers according to my needs to risk a complete reinstallation and reconfiguration just because of an hard disk crash or a single configuration file corruption.